FITC标记的同源盒蛋白MEIS3抗体
产品名称： FITC标记的同源盒蛋白MEIS3抗体
英文名称： Anti-Meis homeobox 3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Meis homeobox 3/FITC Conjugated antibody
FITC标记的同源盒蛋白MEIS3抗体
| 英文名称 | Anti-Meis homeobox 3/FITC |
| 中文名称 | FITC标记的同源盒蛋白MEIS3抗体 |
| 别 名 | Homeobox protein meis3; Meis1 myeloid ecotropic viral integration site 1 homolog 3; Meis1 related protein 2; Meis1-related protein 2 antibodymeis3; MEIS3_HUMAN; MRG2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 信号转导 干细胞 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Dog, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Meis homeobox 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hox, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias. The Hox proteins, which include paralog groups 1-10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (“three amino acid loop extension”) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. Like Hox and Pbx proteins, Meis1 is implicated in oncogenesis, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias. Two Meis-related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas-specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation. Subcellular Location: Nucleus. Similarity: Belongs to the TALE/MEIS homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Homeobox protein meis3; Meis1 myeloid ecotropic viral integration site 1 homolog 3; Meis1 related protein 2; Meis1-related protein 2 antibodymeis3; MEIS3_HUMAN; MRG2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Hox，PBX和MEIS家族的转录因子形成异型复合物，并通过特定的同源盒域结合DNA。Hox蛋白在发育过程中参与调节组织模式，在造血分化和白血病中也以谱系和阶段特异性模式表达。Hox蛋白，包括对偶基团1-10，对DNA具有低的内在结合亲和力，而是与Pbx或与Pbx相关的Meis蛋白结合成协同的DNA结合复合物，这导致增强Hox-DNA结合亲和力和提高对结合位点Meis1和Meis2（也称为Meis相关基因1或Mrg1）都是TALE（“三个氨基酸环延伸”）同源域蛋白家族的成员。除了与Hox蛋白结合外，Meis1还与普遍表达的Pbx蛋白形成异二聚体，包括Pbx1、Pbx2和Pbx3，并且这些复合物含有不同的DNA结合特异性。与Hox和Pbx蛋白一样，Meis1在BHX-2髓系白血病中由于相邻逆转录病毒插入而过表达，因此与肿瘤发生有关。两种Meis相关蛋白，Meis2和Meis3（也分别命名为Mrg1和Mrg2），与Meis1具有非常相似的序列同一性，并在正常组织和髓系白血病中表达。在胰腺中，Meis2优先与Pbx1结合，并且它们一起与胰腺特异性同源域因子Pdx1结合，以抑制Pdx1诱导的转录激活。