FITC标记的脑特异性蛋白BPX抗体
产品名称： FITC标记的脑特异性蛋白BPX抗体
英文名称： Anti-NAP1L2/FITC
产品编号： HZ-11172R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NAP1L2/FITC Conjugated antibody
FITC标记的脑特异性蛋白BPX抗体
| 产品编号 | bs-11172R-FITC |
| 英文名称 | Anti-NAP1L2/FITC |
| 中文名称 | FITC标记的脑特异性蛋白BPX抗体 |
| 别 名 | Brain specific gene BPX; BPX; Brain specific protein, X linked; MGC26243; Nucleosome assembly protein 1 like 2; NP1L2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 染色质和核信号 神经生物学 细胞粘附分子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NAP1L2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Proper nucleosome assembly is critical for compacting DNA into chromatin. In human and mouse there are 5 protein-coding genes which comprise the nucleosome assembly protein (NAP) family. NAP1L1 (NAP1) and NAP1L4 (NAP2) are ubiquitously expressed family members which have been the most extensively studied. The remaining three family members, NAP1L2, NAP1L3 and NAP1L5 are neuron-specific nucleosome assembly proteins translated from intronless genes which are monoallelically expressed. NAP1L2 (nucleosome assembly protein 1-like 2), also known as BPX (brain specific protein, X-linked), is a 460 amino acid protein containing acidic domains which are thought to mediate histone interactions. NAP1L2 binds to chromatin and interacts with Histones H3 and H4. The function of NAP1L2 is not clearly defined although evidence suggests that NAP1L2 influences histone acetylation and therefore may play a significant role in regulating transcription in developing neurons. Function: NAP1L2 is a member of the nucleosome assembly protein (NAP) family. Subcellular Location: Nuclear Similarity: Belongs to the nucleosome assembly protein (NAP) family. Database links: UniProtKB/Swiss-Prot: Q9ULW6.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
合适的核小体组装是将DNA压缩成染色质的关键。在人和小鼠中，有五个编码核小体组装蛋白（NAP）家族的蛋白质编码基因。NAP1L1（NAP1）和NAP1L4（NAP2）是广泛表达的家族成员，是研究最为广泛的成员。其余三个家族成员，NAP1L2，NAP1L3和NAP1L5是从单基因表达的无内含子基因翻译的神经元特异性核小体组装蛋白。NAP1L2（核小体组装蛋白1样2），也称为BPX（脑特异性蛋白，X-连锁），是一种含有酸性结构域的460氨基酸蛋白，被认为介导组蛋白相互作用。NAP1L2结合染色质并与组蛋白H3和H4相互作用。NAP1L2的功能没有明确的定义，虽然证据表明，NAP1L2影响组蛋白乙酰化，因此可能在调节发育中神经元的转录中发挥重要作用。